KMID : 1100920190400040212
|
|
Korean Journal of Family Medicine 2019 Volume.40 No. 4 p.212 ~ p.219
|
|
Frequency and Severity of Hypoglycemia in Type 2 Diabetes Mellitus Patients Treated with a Sulfonylurea-Based Regimen at University-Affiliated Hospitals in Korea: The Naturalistic Evaluation of Hypoglycemic Events in Diabetic Subjects Study
|
|
Kim Yon-Su
Cho Be-Long Kim Woo-Sik Kim Sang-Hyun Jung In-Hyeon Sin Won-Yong Choi Dong-Hoon Lee Sang-Jae Lim Chun-Soo Kang Kyung-Pyo Yu Byung-Yeon Jeung Won-Ju Park Chang-Gyu
|
|
Abstract
|
|
|
Background: We assessed the frequency and severity of hypoglycemia in type 2 diabetes mellitus patients treated with sulfonylurea monotherapy or sulfonylurea+metformin.
Methods: We conducted a retrospective, observational, cross-sectional study in 2011 and 2012 including patients with type 2 diabetes mellitus aged ¡Ã30 years who were treated with ¡Ã6 months of sulfonylurea monotherapy or sulfonylurea+metformin at 20 university-affiliated hospitals in Korea. At enrollment, glycated hemoglobin (HbA1c) was assessed; participants completed self-reported questionnaires describing hypoglycemia incidents over the past 6 months. A review of medical records up to 12 months before enrollment provided data on demographics, disease history, comorbidities, laboratory results, and drug usage.
Results: Of 726 enrolled patients, 719 were included (55.6% male); 31.7% and 68.3% were on sulfonylurea monotherapy and sulfonylurea+metformin, respectively. Mean¡¾standard deviation age was 65.9¡¾10.0 years; mean HbA1c level was 7.0%¡¾1.0%; 77.8% of patients had hypertension (89.4% used antihypertensive medication); 60.5% had lipid disorders (72.5% used lipid-lowering medication); and 52.0% had one or more micro- or macrovascular diseases. Among patients with A1c measurement (n=717), 56.4% achieved therapeutic goals (HbA1c <7.0%); 42.4% (305/719) experienced hypoglycemia within 6 months of enrollment; and 38.8%, 12.9%, 12.7%, and 3.9% of patients experienced mild, moderate, severe, and very severe hypoglycemia symptoms, respectively. Several reported hypoglycemia frequency as 1?2 times over the last 6 months. The mean number of very severe hypoglycemia episodes was 3.5¡¾5.5.
Conclusion: Among type 2 diabetes mellitus patients treated with sulfonylurea-based regimens, glycemic levels were relatively well controlled but hypoglycemia remained a prevalent side effect.
|
|
KEYWORD
|
|
Glycated Hemoglobin A, Hypoglycemia, Sulfonylurea, Type 2 Diabetes Mellitus, Metformin
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|